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eric:J Neurosci:基因变异导致特发性震颤  IP:61.153.7.71  日期:2012-9-12 [回复11楼]

  J Neurosci:基因变异导致特发性震颤
  作者:蓝建中
  来源:新华社
  2012-8-26 关键词: 基因变异 特发性震颤 髓鞘
  
  
  8月21日,东京医科齿科大学的研究人员美国《神经科学期刊》(Journal of Neuroscience)上报告说,他们在对实验鼠的神经回路进行分析的过程中,发现导致手脚和头部震颤的致病基因。
  
  特发性震颤是临床常见的运动障碍疾病,其临床表现是“姿势性震颤”,即肢体维持一定姿势时引发的震颤,在肢体完全放松时震颤自然消失。
  
  日本的统计数据显示,在超过40岁的人群中,每20人当中有1人患特发性震颤,65岁以上人群中则每5人就有1人患此病。特发性震颤被认为是基因原因所致,但与此相关的具体基因及其引发症状的详细机制此前一直不明。
  
  研究人员分析了行走时下半身出现强烈震颤症状的实验鼠的基因及其中枢神经系统,发现实验鼠的“Teneurin-4”基因出现变异,导致神经细胞的轴突外没有形成髓鞘。神经类似电线,轴突相当于电线中的导线,而髓鞘如同覆盖在导线外的绝缘层。
  
  另外,研究人员确认“Teneurin-4”基因功能受到抑制的转基因实验鼠也存在髓鞘发育不全的状况。
  
  研究人员认为,实验鼠是由于髓鞘没有正常形成,导致神经回路“短路”,才出现震颤症状(这是重点)。人类也有功能相同的基因,所以发生这种震颤的原因很可能也一样。
  
  该研究小组带头人、东京医科齿科大学讲师铃木喜晴认为,如果能控制上述致病基因,就有可能开发出治疗特发性震颤的药物。
  (有研究认为OMEGA-3对髓鞘有帮助,以及其他,供参考) 

eric:回复7楼 skys 自行车在作临床试验  IP:61.153.7.71  日期:2012-12-12 [回复12楼]

  回复7楼 skys 自行车在作临床试验
  回复7楼 skys:脚踏车Pedaling for Parkinson’s...and dystonia
  
  http://clinicaltrials.gov/ct2/show/NCT01636297(联接)
  
  The Cyclical Lower-extremity Exercise for Parkinson’s Trial (CYCLE)
  Purpose
  The purpose of this study is to gain a better understanding of how exercise training affects motor/hand function and brain function in those diagnosed with Parkinson’s disease. The investigators want to study if exercise will improve hand function and improve the level of brain activity.
  ..........
  
  已经到了实验3期 

eric:Parkinson’s Disease and Intense Exercise: Neil Sligar’s 10-Year Experience  IP:61.153.7.71  日期:2012-12-14 [回复13楼]

  Parkinson’s Disease and Intense Exercise: Neil Sligar’s 10-Year Experience
  回复12楼 eric:回复7楼 skys 自行车在作临床试验
  一个西方人锻炼10年经历,心得(包括室内自行车和划船)
  http://katekelsall.typepad.com/my_weblog/2010/01/parkinsons-disease-and-intense-exercise-neil-sligars-10-year-experience.html
  
  峰值功率有点大 

Eric:热量限制  IP:58.100.178.242  日期:2012-12-21 [回复14楼]

  热量限制
  
  你有没有吃饭后感到无法工作的经历?少吃一点有助于头脑清醒,这可能有科学依据。意大利研究人员在美国新一期《国家科学院学报》上发表报告说,动物实验显示,减少热量摄入可以更持久地保持大脑健康。
  
  罗马圣心天主教大学研究人员发现,与过度进食的实验鼠相比,限制热量摄入的实验鼠不会患糖尿病,认知和记忆能力也更佳。此外,它们不容易患阿尔茨海默氏症(早老性痴呆症),即使患病,时间也会推迟,症状也比过度进食的实验鼠轻。在这项研究中,热量限制意味着实验鼠进食不超过日常所需的70%。
  
  研究人员进一步发现,限制热量摄入激活了实验鼠大脑内的环腺苷酸反应成分结合蛋白1,后者进而能激活其他一系列与长寿相关的分子。而清除该物质后,实验鼠即便限制热量摄入,也会与过度进食者或老年者一样出现大脑功能衰退。
  
  研究人员表示,他们今后的研究方向是通过新药物等方式激活环腺苷酸反应成分结合蛋白1,这样不限制热量摄入也能保持大脑健康。(生物谷 Bioon.com)
   

向左向右:回复13楼 eric  邮箱:ppokok@126.com  IP:121.32.58.107  日期:2012-12-24 [回复15楼]

  回复13楼 eric
  回复13楼
  
  很好的例子,她的一句话我很有同感:
  I respect and am grateful for the opinions of those in the medical and physical therapy professions but the final say in managing my Parkinson’s should be mine.
  我尊重,我感激他人在医疗和物理治疗专业方面的研究观点,但最终管理我的帕金森氏症的决定权应该属于我自己。
   

eric:身体(体力)活动减低阿尔茨海默病前体蛋白  IP:124.160.209.230  日期:2013-2-7 [回复16楼]

  身体(体力)活动减低阿尔茨海默病前体蛋白
  http://www.sciencewa.net.au/topics/health-a-medicine/item/1899-alzheimer%E2%80%99s-disease-precursor-protein-lowered-by-physical-activity.html
  
  2013.2.1
  Alzheimer’s disease precursor protein lowered by physical activity
  
  A STUDY examining the link between physical activity and Alzheimer’s disease suggests physical activity may reduce the risk of developing Alzheimer’s; lowering levels of neurotoxic protein amyloid-β and improving cognition and memory in healthy older adults.........
  
   

eric:帕金森康复峰会 报告 2013 第3届年会 新墨西哥 圣达菲  IP:61.153.7.71  日期:2013-2-27 [回复17楼]

  帕金森康复峰会 报告 2013 第3届年会 新墨西哥 圣达菲
  Parkinson’s Recovery Summit trip report
  the 3rd annual Parkinson’s Recovery summit held this past weekend in Santa Fe, New Mexico.
  Here’s what I attended and my key take-aways:(3是讲气功事例)
  
  1.“Releasing Pain and Emotional Stress” – John O’Dwyer. He was a computer programmer for 37 years and his wife has PD. He talked about how emotional issues, stress and trauma are tied to our pain and Parkinson’s and presented some techniques to help with relief. One technique involves EFT tapping which is free to learn and do, but perhaps not for everyone (moderate woo factor score). I liked this guy and will look into some of his ideas.
  
  2.“Neuro Feedback” – Jaclyn Gisburne. Her talk also discussed how the effects of traumatic events, perhaps even from early childhood, could influence the Parkinson’s condition. One interesting topic she discussed was the use of “Eagala horse therapy” – where a PwP was introduced to some horses and one of the horses picked up on the person’s tremor. The 2 connect and there’s some “healing” takes place. The 2 times I attempted to ride a horse long ago were not good so maybe I should look into this! You can google “Eagala” to learn more. Eagala is a non-profit organization in which horses are used in the treatment of mental health.
  
  3. “Qigong for Parkinson’s” – Bianca Molle and Mingtong Gu. These were 2 separate presentations both covering the healing properties of a Qigong practice. Bianca is a former school teacher who claims to have healed her symptoms of Parkinson’s by a daily 3hour practice and guess what, I believe her! I’ve met her in person, taken a one-on-one class with her and she’s a delightful high energy former PwP and very credible. Her neurologist no longer wants to see her! Mingtong Gu is from China and this guy is “Mr. Qigong”. His whole session involved us doing a variety of qigong exercises and movements to awaken our minds and bodies – a good thing since his talk was the last of the day at 4pm. Now here’s the amazing part for me – for the past year I’ve had some pain in my right shoulder whenever I extend my arm backwards (putting on jackets, reaching up etc.) It’s been getting worse, so much so that I went to the Dr. a few weeks ago (a rare thing for me) and have scheduled a series of physical therapy appointments. Mingtong led us through some warm up exercises to “activate” our Qi (or Chi) and guess what – after doing this for 5 minutes or so, my shoulder felt much better for the next several hours. So much so that during the talk I stood up, went to the back of the room and played around with my arm to convince myself it was real, and it was. Well, that’s my success story and I’m hooked on Chi!
  
  4. “Deciding Success with Parkinson’s” – John and Bernadette Baumann. John is a former Exxon trial lawyer, inspirational speaker and a PwYOPD – his focus is on diet and exercise beyond our comfort zone. His goal is to be the slowest progressing PwP in medical history and guess what, he looks great. His message is don’t exercise, but train – push yourself with higher intensity to get best results. Have a goal and decide success. He walks the talk.
  
  5. “Heal PD with LDN” – Marlene (Lexie) Lindstrom. Lexie is the “Poster Child for LDN” – anyone who looks that good at that age (yes, during her talk she told us her age – wow!) and of course she’s well known to the PLM group. She shared with us her remarkable healing journey and handed out a packet of useful reference material. She also introduced us to a lady in the audience who shared her own LDN success story – this person similarly looked great and told us she is working with neurologists from Duke University to document her results.
  
  What were my 4 key learning’s from the conference? –
  
  1. We all must exercise and push hard at higher levels of intensity and get out of our comfort zone. I used to go to the gym and do the same 30min exercise program on a stationary bike. Now I set goals and aim higher. I’m no doctor, so please consult with your physician before starting this.
  
  2. Qigong is easy and free to do (youtube it) and really gets your energy flowing. You can do this sitting down if you need to and the long term results are very beneficial for PD.
  
  3. If I reach the stage where my quality of life demands drugs – I will start off with an LDN program.
  4. This may stir up some people – but almost all the presenters that I heard expressed a belief in a higher power/universal consciousness or whatever you want to call it. So there!
  
  Finally I must thank and acknowledge the work of the conference organizer, Robert Rodgers, Ph.D. He did an amazing job to pull together all the presentations. His mother had Parkinson’s and his passion is to help persons with Parkinson’s feel better using approaches that are natural and have no side effects. He has a free weekly internet radio show – sometimes the topics and presenters are “out there” and other times it’s just plain good useful stuff for us PwPs. You don’t have to listen to every show! Also each show is archived so you can download. He’s definitely not in this to make money!
  
  
  
   

eric:回复7楼 skys  IP:61.153.7.71  日期:2013-3-8 [回复18楼]

  回复7楼 skys
  回复7楼 skys:脚踏车
  
  http://medicalxpress.com/news/2013-03-intervention-syndrome.html
  
  <Researcher finds exercise may be intervention for Down syndrome>2013.3.6
  
  研究人员发现锻炼可能干预唐氏症--固定式脚踏车
  
  虽然不是直接关于PD...... 

eric:ARD:维生素D可通过增强线粒体功效使肌肉充满能量  IP:58.100.172.69  日期:2013-4-10 [回复19楼]

  ARD:维生素D可通过增强线粒体功效使肌肉充满能量
  维生素D可通过增强线粒体功效使肌肉充满能量
  
  2013-4-9 关键词: 维生素D 线粒体 肌肉 能量
  
  Akash Sinha博士目前所从事的一项研究表明补充维生素D可以增强线粒体的活性,从而达到增强肌肉功能的效果.
  
  人的皮肤在太阳光能的作用下可产生维生素D,当也有一部分食物中存在该物质,这类包括鱼、鱼肝油、鸡蛋黄和一些强化谷物食品等,但通过服用维生素D补充剂是最有效的方式.
  
  在英国大约有60%的人患有维生素D缺乏症,这些人群中有5岁以下的孩子,肌肤黝黑和暗黄人群,身体容易受到损害的老年人等.维生素D能够促进骨骼的形成,防治佝偻病的发生,这一观念目前已经广为人知,对于这种维生素影响人体健康的其他方面也在进一步研究当中.
  
  研究者采用无创核磁共振扫描测定了12例维生素D缺乏患者在服用维生素D补充剂前后对身体运动产生的应答变化.该项研究的首席作者Akash Sinha博士供职于纽卡斯尔医院信托基金会,他说:“这一扫描结果为我们理解肌肉正常运作中综合认识维生素D所发挥的作用提供了全面的视觉”.
  
  科学家对一组维生素D缺乏且已经出现肌肉疲劳症的患者进行检查,结果发现当给那些体内维生素D水平极低的患者服用维生素D补充剂时,他们的肌肉活力就会明显得到改善.
  
  维生素D缺乏患者除了表现为骨骼运动能力差、肌肉疲劳症以外,这些症状也会使线粒体的工作效率降低,因为线粒体是人体中细胞的“发电站”.
  
  线粒体可以利用血糖和氧气在细胞内形成能量,从而使细胞正常运转,这一富含能量的分子物质称之为ATP.肌肉细胞的运动需要利用大量的ATP,并且以磷酸肌酸作为可利用的库存资源以便制造ATP.当肌肉发生萎缩时线粒体会调动磷酸肌酸的库存供自己利用,所以通过测定线粒体补充磷酸肌酸库存的时间可以用来衡量线粒体的工作效率.线粒体的功能越强磷酸肌酸恢复的时间就越短.
  
  研究组发现当患者连续10-12周服用固定量的维生素D补充剂时,线粒体中磷酸肌酸的恢复速率就会明显提高.平均恢复速率从开始的34.4/s到后来的27.8/s.所有的患者服用补充剂后肌肉疲乏的程度减轻了.而在对照组中,低维生素D水平的患者同时表现为线粒体功能的下降.
  
  Sinha博士说:“我们首次阐明了维生素D与线粒体功能之间的联系,受试者中约有60%的人群属于维生素D缺乏者,而这些人大多住在曼彻斯特北部,他们也正试图通过接受阳光来补充维生素D,特别是在春天和冬天的时候.其实,一粒简易的维生素D药片就能让你的身体充满能量”. 

eric:回复19楼 eric  IP:58.100.172.69  日期:2013-4-10 [回复20楼]

  回复19楼 eric
  维生素D可能有神经保护作用
  
  http://www.lef.org/newsletter/2013/0322_Vitamin-D-Slows-Parkinsons-Progression.htm?utm_source=eNewsletter&utm_medium=email&utm_term=Article&utm_content=Button&utm_campaign=2013Wk12-2&l=0#article
  
  
  Vitamin D slows Parkinson’s progression
  
  
  Friday, March 22, 2013. The results of a double-blind, placebo-controlled trial reported online on March 13, 2013 in the American Journal of Clinical Nutrition reveal a benefit for vitamin D supplementation in men and women with Parkinson’s disease.
  ...........
  关键词:东京慈恵会医科大学 114病人参试 1200IU(剂量) 12个月
  可能是第一个关于维生素D的临床试验
  
  以下是相关讨论,在英国PD论坛:
  
  http://www.parkinsons.org.uk/pdsforum/posts.aspx?forum=research&topic=vitamine-d-trial-possible-neuroprotection&page=1
  
  Vitamine D trial: possible neuroprotection
  
  那里有人说吃1800IU,5000IU每天的,认为过去几年发展轻微,也有说澳大利亚比英国发病率高的,请参考。Vitamin D比较便宜(ebay),可能还有防骨质疏松的作用等。
  
  相关论文:
  http://ajcn.nutrition.org/content/early/2013/03/12/ajcn.112.051664.abstract
  
  Randomized, double-blind, placebo-controlled trial of vitamin D supplement in Parkinson’s disease
  
  论文中说是VITAMIN D3
  
  
   

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